Aspartic acid, tseem hu ua aspartate, yog tsim nyob rau hauv daim siab los ntawm cov kab mob los ntawm glutamate. Nws lub luag haujlwm tseem ceeb yog tsim thiab thauj lub zog thoob plaws hauv lub cev. Kab lus no yuav tham txog nws cov metabolism, nqus tau, thiab cov tshuaj lom.
Metabolism
Aspartic acid yog synthesized nyob rau hauv lub siab los ntawm glutamate thiab tso siab rau cov cofactor pyridoxine (vitamin B6) rau nws hloov dua siab tshiab. Asparagine yog tsim los ntawm aspartic acid thiab adenosine triphosphate (ATP), tab sis nws tseem tuaj yeem tsim los ntawm glutamate, xav tau cov ntxhia magnesium.
Cov ntaub ntawv thiab kev nqus ntawm aspartic acid
Aspartic acid muaj nyob rau hauv ob hom: L-aspartic acid thiab D-aspartic acid. Cov zaub mov muaj protein ntau muaj L-aspartic acid (ie, L-aspartic acid). Aspartic acid thiab glutamate sib tw rau kev nqus hauv lub hlwb, cortex, thiab qaum qaum. Qhov kev sib tw nqus no yog ib txoj hauv kev amino acid metabolism tswj lub cev.
Kev nqus ntawm aspartic acid thiab glutamate txo qis hauv lub hlwb puas. Zoo li lwm yam excitatory neurotransmitters, aspartic acid txo qis hauv cov ntshav ntawm cov neeg mob kev nyuaj siab. Tam sim no, aspartic acid tau raug tshuaj xyuas rau nws siv hauv kev kho kev nyuaj siab.
Aspartic Acid Toxicity thiab Side Effects
Aspartic acid toxicity zoo ib yam li cov monosodium glutamate (SG). Kev noj tshuaj ntau ntawm aspartic acid ua rau muaj kev puas tsuaj rau lub hauv nruab nrab paj hlwb hauv cov tsiaj sim, tshwj xeeb tshaj yog hypothalamus, ua rau rog rog, kev loj hlob qeeb, thiab kev ua me nyuam tsis ua haujlwm. Aspartic acid tuaj yeem txo lub cev muaj zog thiab tshawb xyuas tus cwj pwm hauv cov tsiaj sim. Nws kuj tseem tuaj yeem txo qis fertility (qhov txawv txav ntawm aspartic acid enzymes hauv cov phev txawv txav), txo qhov ntim ntawm cov qog pituitary, cov thyroid caj pas, zes qe menyuam, thiab cov qog ntshav, thiab ua rau cov retina thiab kev puas tsuaj, ua rau retinal detachment. D-aspartic acid yog tshuaj lom ntau dua li L-aspartic acid, ua rau kev loj hlob inhibition hauv cov tsiaj sim. Cov koob tshuaj aspartic acid siv nyob rau hauv cov kev tshawb fawb no yog kwv yees li 2 mus rau 4 grams ib kilogram ntawm lub cev qhov hnyav, sib npaug rau 140 mus rau 280 grams hauv 70-kilogram tus txiv neej laus-ib koob tshuaj ntau tshaj li kev siv lub cev lossis kev kho mob. Qhov ncauj koob tshuaj txog li 25 mus rau 100 grams ntawm aspartic acid yuav tsis ua rau muaj kev phiv tshuaj lom rau tib neeg.
Kev ceev faj rau kev haus aspartame
Aspartic acid thiab phenylalanine yog cov khoom siv raw rau kev tsim aspartame. Hmoov tsis zoo, ob qho tib si tuaj yeem txhawb txoj hauv kev zoo siab hauv lub hlwb. Txoj kev excitatory no tuaj yeem ua rau mob hnyav, khaus khaus, mus ob peb vas, thiab txawm tias cuam tshuam nrog kev puas siab puas ntsws. Lawv tuaj yeem ua rau tag nrho lub cev, nrog rau lub ntsws thiab lub hlwb, los ntawm nag lossis daus, piv txwv li, hauv Alzheimer's disease.
Aspartame yog ib qho kev hloov suab thaj tshwj xeeb. Vim tias nws yog dipeptide compound thiab tawg sai, nws muab lub zog qab zib saj, ntau pua lub sij hawm qab zib dua li qabzib, tab sis muaj calories tsawg heev. Hauv kev tshawb fawb ntawm aspartame, qhov ntau npaum li cas siv yog 34 mg / kg lub cev hnyav, uas yog sib npaug rau 2 grams ntawm aspartic acid nyob rau hauv nruab nrab 70 kg neeg laus. Qhov koob tshuaj no tsis txaus kom nce qib ntshav ntawm aspartic acid, asparagine, lossis glutamine; Yog li, peb tuaj yeem pom tias aspartame muaj kev nyab xeeb siv. Txawm li cas los xij, qhov no tsis siv rau cov neeg mob uas muaj phenylketonuria.