【English Name】 L-Aspartic Acid
【Molecular Formula】 C4H7NO4
【Molecular Luj】 133.10
【CA Registry Number】 [1191-15-7]
【Abbreviations and Synonyms】 Asp thiab D
【Structural Formula】 HO2CCH2CH(NH2)CO2H
【Physical Properties】 (S)-(+): [α20D] +25°, mp >300 oC (decomposes); (R)-(–): [α20D] –24°, mp>300 oC (decomposes); (±): mp 325 ~ 348 oC (decomposes). Nws yog soluble hauv acids thiab bases, insoluble hauv ethanol; nws solubility nyob rau hauv dej yog 1 g / 222.2 mL (20 oC), thiab nws yooj yim tsim supersaturated daws [1]. 【Kev Npaj thiab Kev Siv Ua Lag Luam】 Cov reagent no yog cov khoom lag luam muag muag, feem ntau yog haiv neeg lossis optically dawb huv.
【Kev ceev faj】 Cov reagent no yog ib yam khoom ntuj tsim thiab tsis yog - lom.
L-Aspartic acid feem ntau yog siv los ua chiral substrate rau diastereoalkylation cov tshuaj tiv thaiv thiab tseem tuaj yeem siv los ua cov chiral los ua ke lwm cov tshuaj chiral.
Diastereselective Alkylation
L-Aspartic acid esters tuaj yeem nkag mus rau alkylation ntawm - thiab - txoj haujlwm (Formula 1), nrog -alkylation yog qhov siv dav tshaj plaws. Nyob rau hauv - txheej txheem alkylation, cov amino acid moiety muaj feem cuam tshuam rau diastereoselectivity ntawm cov tshuaj tiv thaiv. Ib txhij, -dicarbonyl compounds kuj tuaj yeem npaj los ntawm -alkylation ntawm cyclic derivatives ntawm L-aspartic acid. Diastereselective Alkylation
Synthesis ntawm Chiral Compounds
Siv L-aspartic acid ua ib qho chaw chiral, cov kab sib txuas ntawm cov chiral tuaj yeem ua ke. Piv txwv li, siv cuprous iodide, sodium borohydride, thiab lwm yam, tuaj yeem ua rau muaj ntau yam oxo-nitrogen heterocyclic compounds (Sib npaug 2), uas tuaj yeem tsim cov quinoline txuas ntxiv.
Synthesis ntawm Chiral Compounds
Amide Bond Tsim
L-aspartic acid, raws li ib qho amino acid, tuaj yeem tsim cov tshuaj amide zoo li lwm cov amino acids (Kev sib npaug 3).
Amide compounds
Ib txhij, L-aspartic acid kuj tseem siv tau los ua cov niam txiv sib xyaw ua ke los tsim cov cyclic lactams, xws li rau -cov tswvcuab cyclic lactams (Equation 4). Cov khoom lag luam kuj muaj cov pab pawg alkoxy, uas tuaj yeem ua lwm qhov chaw tshuaj tiv thaiv rau ntxiv derivatization.
Synthesis ntawm -Amino Acids (los yog Amino Acid Esters)
L-aspartic acid, tom qab kev tiv thaiv amino thiab alkylation, tuaj yeem tsim tau -amino acids lossis amino acid esters (Equation 5). Cov tshuaj tiv thaiv no ua tiav cov kev hloov pauv los ntawm cov amino acids ntuj mus rau tsis yog -natural amino acids. Synthesis ntawm -amino acids (los yog amino acid esters)
Tsis tas li ntawd, L-aspartic acid muaj ob pawg carboxyl thiab ib pawg amino, yog li nws tuaj yeem ua raws li polydentate ligand los koom tes nrog cov hlau ions [7-9] lossis tsim cov lactone compounds nws tus kheej.